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Recommendations for Interventions by the Effective Interventions and Strategies Workgroup 

 

HIV Positive Person - Individual Level Interventions

HIV Positive Person - Prevention Case Management

HIV Positive Person - Group Level Interventions

HIV Positive Person - Partner Notification

HIV Positive Person - Other

HIV Positive Interventions Summary (includes 2007 updates) (PDF 106kb)

2007 HIV Positive Interventions (new only) (PDF 31kb)

HIV Positive Persons

Literature Summary

Individual-Level - HIV Positive Person
Patterson, T. L., Shaw, W. S., & Semple, S. J. (2003) Reducing the sexual risk behaviors of HIV-positive individuals: Outcome of a randomized control trial. Annals of Behavioral Medicine, 25, 137-145
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + Person This study evaluated an intervention designed to reduce sexual risk behaviors of HIV positive persons.  The basis for this intervention was the social-cognitive theory (SCT).  There were 387 HIV positive persons who reported having unprotected sex with HIV negative partners or partners of unknown status selected and randomly assigned to one of four intervention conditions. (1) a single counseling sessions targeting problem areas identified by the participant; 2) a single session that covered all three intervention domains; 3)  the same comprehensive intervention followed by 2 monthly boosters; and 4) a three session diet and exercise attention-control conditions.  The ethnic minority composure of those participating in the intervention consisted of the following: 65% non-Hispanic white, 15% African American, 12% Hispanic and 8% other. The majority of the participants were male (91%); female participants consisted of 9%. The results suggest that brief behavioral interventions designed to promote safer sex among HIV positive persons can result in large reductions in HIV transmission.  The use of a brief SCT-based intervention for HIV positive persons, targeting condom use, negotiation of safer sex practices, and disclosure can result in reductions in sexual behavior associated with HIV transmission.
Richardson, J. L., Milam, J., McCutchan, A., Stoyanoff, S., Bolan, R., Weiss, J., Kemper, C., Larson, R. A., Hollander, H., Weismuller, P., Chou, C. P., & Marks, G. (2004). Effects of brief provider safer-sex counseling of HIV-1 seropositive patients: A multi-clinic assessment. AIDS, 18, 1179-1186
Subpopulation Researched Intervention Design Evaluated Outcome

HIV + Person

 Implementing of Integrating Prevention Services into Medical Care for People Living with HIV

The objective of this intervention was to test the efficacy of a brief safer-sex counseling intervention for HIV positive clients conducted by their medical providers.  Six HIV clinics participated in the intervention.  Two clinics (214 clients) used gain-frame messages, two clinics (175 clients) used loss-frame messages, and two clinics (196) were attention-control clinics.  The counseling was a short 3-5 minute session and delivered to all HIV positive clients who agreed to participate.  The short messages were delivered each time the client visited the medical provider’s office. The intervention trail found that brief safer sex counseling provided by medical providers can be effective in reducing risky sexual behavior.  The lost-frame intervention reduced unsafe sex in clients with multiple or casual partners.  There was not a reduction in those clients who had one partner at baseline interviews; those clients had a much lower prevalence of UAV at intake making it difficult for the intervention to reduce the occurrence.
Fisher, J. D., Cornman, D.H., Osborn, C. Y., Amico K. R., Fisher, W. A., & Friedland, G., A.. (2004) Clinician-initiated HIV risk reduction intervention for HIV-positive persons; Formative research, acceptability, and fidelity of the Options project. Journal of Acquired Immunodeficiency Syndromes, 37, S78-S87.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + Heterosexual The theoretical foundations for this intervention are motivational interviewing (MI) and information-motivation behavioral skills (IMB).  Research with 231 clients and practitioners resulted in the formulation of this intervention.  Options is a “shell” or framework a clinician uses to elicit the dynamics of HIV risk behavior and to assist in creating a tailored HIV risk reduction intervention for their HIV positive clients.  Options is a 5 – 10 minute collaborative client-centered discussion.  There was a 9 step protocol outlined for the clinician to follow.  Each clinician received practitioner training in order to conduct the intervention. The Options intervention was well accepted as a component of routine HIV care.  It was found to be acceptable and capable of being delivered with fidelity in clinical care.  The results revealed patients exposed to the protocol reduced HIV sexual risk behavior significantly over time.
Padian NS, O’Brien TR et al. (1993) Prevention of Heterosexual Transmission of Human Immunodeficiency Virus Through Couple Counseling. Journal of Acquired Immunodeficiency Syndrome. 6(9): 1043-8
Subpopulation Researched Intervention Design Evaluated Outcome
HIV+ Heterosexual 144 HIV infected individuals and their heterosexual partners. Every six months, each member of the couple was interviewed separately by a staff member to obtain demographic and behavioral information and offer couple counseling.  Couples were counseled together for first session on how to purchase, store and use condoms; how to refrain from practicing anal sex; how to choose abstinence; and how not to enter into sexual relations with new partners The intervention was effective at improving safer sex behaviors, with change occurring between initial enrollment and the first follow up.  85% of the couples who did not use condoms at initial enrollment did so by the most recent follow-up.  During the intake interview, 49% reported condom use.  During the 1st follow-up, 88% reported condom use.  Other behavior changes were also made.
Fisher D, Ryan R, et al. (1999). Using a community partnership and motivational interviewing to serve HIV+ gay and bisexual men. National HIV Prevention Conference, 1999 [Abstract no. 680].
Subpopulation Researched Intervention Design Evaluated Outcome
HIV+ Preliminary report. 107 HIV+ MSM who had anal sex in preceding 4 months with a male partner. Using motivational interviewing, assess values, beliefs, attitudes, and details on 4 most recent anal sex partners. In discussion, highlight discrepancies between values, beliefs, and risky sexual behaviors. Six-month follow-up data show a 31% reduction in the proportions of participants reporting unprotected anal sex with a partner of negative or unknown serostatus.
Wyatt, G. E., Lonngshore, D., Chin, D., Carmona, J. H., & Rivkin, I. (2004). The efficacy of an integrated risk reduction intervention for HIV-positive women with child sexual abuse histories. AIDS and Behavior, 8, 453-462
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + Women

It was believed that child sexual abuse history (CSA) is associated with HIV risk behaviors.  This randomized trial tested the impact of a culturally psychoeducational intervention designed to reduce sexual risk and increase HIV medication adherence for HIV positive women with a history of CSA.  The study included African American, European America, English-speaking and monolingual Spanish-speaking Latina.  Once recruited, 147 women were randomly assigned to an 11 session “Enhanced Sexual Health Intervention (ESHI)” or and attention control group.  Women assigned to the control group received a one-time group meeting where they received HIV prevention and CSA information.  Women assigned to the ESHI condition attended 11 weekly sessions each lasting approximately 2.5 hours.

Women in the ESHI condition reported greater sexual risk reduction than the women in the control condition.  The difference between the intervention (75.6%) and control group (73/3%) were roughly the same concerning medication adherence.  However, women in the ESHI condition who attended at least 8 sessions reported great medication adherence (91.3%) at the posttest than the women who attended seven or fewer sessions (49.7%).  The unadjusted percentage of women reporting sexual risk reduction at posttest was higher in the ESHI group (63.6%) than in the attention control group (56.8%).  This was not considered statistically significant. When  adjusted for covariates, the results were ESHI 74.5% and attention control group 54.4%.
Prevention Case Management - HIV Positive Person                                              Back to Top                                     
The CDC has endorsed Prevention Case Management (PCM) as an effective intervention to reach HIV positive and/or very high-risk HIV negative persons.  PCM is a client-centered HIV prevention activity with the fundamental goal of promoting the adoption and maintenance of HIV risk reduction behaviors by clients with multiple, complex problems and risk reduction needs.  PCM provides client-centered, multiple-session HIV risk reduction counseling while using the service brokerage of traditional case management to address competing needs that may make HIV prevention a lower priority.  This HIV prevention activity addresses the relationship between HIV risk and other issues such as substance use, mental health, adherence issues, social and cultural factors, and physical health problems.  While PCM has yet to be rigorously evaluated, intensive case management interventions for clients with multiple, complex problems have been shown to be effective in other health fields.

CDC HIV Prevention Case Management – Guidance   September 1997

CDC HIV Prevention Case Management – Literature Review and Current Practice   September 1997

CDC Abbreviations and Acronyms

Group-Level - HIV Positive Person                                                                           Back to Top

Carey, M. P., Carey, K. B., Maisto, S. A., Gordon, C. M., Schroder, K. E. E., & Vanable, P. A. (2004). Reducing HIV risk behavior among adults receiving outpatient psychiatric treatment: results from a randomized controlled trial. Journal of Counseling Clinical Psychology. April 2004 v74 i2 p252 (17)

Subpopulation Researched Intervention Design Evaluated Outcome

HIV + Heterosexual

This study investigated the efficacy of a 10 session, HIV risk reduction intervention.  There were 211 women and 187 men, receiving outpatient psychiatric care for mental illness, who participated in this intervention.  Clients were randomly assigned to one of three situations: HIV risk reduction intervention, structurally equivalent substance use reduction intervention, or standard care.  Clients were assessed pre and post intervention and at 3 and 6 month follow-up appointments. Compared to clients assigned to the other two situations, clients assigned to the HIV risk reduction intervention reported less unprotected sex, fewer casual partners and fewer new sexually transmitted infections.  They also reported more- safer sex communications, improved knowledge, behavioral skills, more positive condom attitudes, and stronger condom use intentions.
Wingood, G., M., DiClemente, R. J., Mikhail, I., Lang, D. L., McCree, D. H., Davies, S. L., Mardin, J. W., Hook, E. W. 3rd, Saag, M. (2004).  A randomized controlled trial to reduce HIV transmission risk behaviors and sexually diseases among women living with HIV: The WILLOW program. Journal of Acquired Immunodeficiency Syndromes, S58-S67
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + Women The WILLOW (women involved in life learning from other women) object was to evaluate the efficacy of this intervention to reduce HIV transmission risk behavior, STDs and enhance HIV prevention psychosocial and structural factors among women living with HIV.  Once recruited, 366 women were randomly assigned to the comparison group or to the intervention.  Women assigned to the comparison group participated in four 4 hour sessions that addressed: medication adherence, nutrition, and provided interaction skill.  Women assigned the intervention group also attended four 4 hour sessions, but there sessions focused on knowledge, attitudes, self-efficacy, and skills regarding safer sex. Over the 12 month follow-up, women in the intervention reported: fewer episodes of unprotected vaginal intercourse, less likely to report never using condoms; lower incidence of bacterial infections; greater knowledge and condom self-effeminacy; more network members; fewer beliefs that condoms interfere with sex; fewer partner related barriers to using condom use; and demonstrated grater skills in using condoms.
Fogarty LA, Heilig CM, Armstrong K, et al. (2001). Long-Term Effectiveness of a Peer-Based Intervention to Promote Condom and Contraceptive Use among HIV-Positive and At-Risk Women. Public Health Reports 116: S103-S119.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV+ women HIV infected women in one study (N=322, Baltimore) and women at high risk for HIV infection in a second study (N=1289, Philadelphia) assigned to a standard or enhanced HIV prevention treatment group. Standard intervention was access to Title X comprehensive health services throughout study. The enhanced intervention added support groups and one-on-one contacts with peer advocates tailored to clients’ needs. Based on Stage of Change Theory. Measurements at baseline, 6 months, 12 months, and 18 months. For HIV infected women, enhanced group had improved consistency in condom use, increased perceived advantages of condom use, and increased self-efficacy. For women at-risk, enhanced group showed no sustained advantage over standard group.
Coates TJ, McKusick L et al. (1989). Stress-reduction training changed numbers of sexual partners but not immune function in men with HIV. American Journal of Public Health 79: 885-7
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + MSM 64 HIV+ gay men randomly assigned to 1) eight 2-hour weekly group stress reduction training session plus one all day retreat, or 2) a 2 month wait-list control. At 2-month follow-up, experimental group had fewer sexual partners in the past month than control group (1.1 vs. 2.3).
Kalichman SC, Rompa D, Cage M, et al. (2001). Effectiveness of an Intervention to Reduce HIV Transmission Risks in HIV-Positive People. American Journal Preventive Medicine 21(2): 84-92.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV+ and African-American

"Health Relationships"

233 men and 99 women living with HIV/AIDS randomly assigned to receive either 1) a five-session group intervention focused on strategies for practicing safer sexual behavior, or 2) a five-session, contact-matched, health-maintenance support group (standard-of-care comparison). 74% of participants were African-American. Based on Social Cognitive Theory, emphasizing building behavioral skills, enhancing self-efficacy for practicing risk-reduction behaviors, promoting intentions to change, and developing strategies for change. Framed intervention content within context of managing stress related to HIV disclosure and practicing safer sexual behavior. The five 120-minute sessions were delivered at the rate of two per week using gender-specific presentations.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

Outcomes measured immediately post intervention, 3 months, and 6 months. 78% retention at 6 months. At 6-month follow-up, intervention group reported fewer HIV negative partners, less unprotected anal and vaginal intercourse, and greater condom use.
Kelly JA, St. Lawrence JS et al. (1989). Behavioral intervention to reduce AIDS risk activities. Journal of Consulting and Clinical Psychology 57: 60-7.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV +, negative, or unknown status high-risk MSM

"Many Men, Men Voices"

104 participants randomly assigned to 1) 12 weekly sessions, 75-90 min small group counseling which provided AIDS risk information, behavioral self-management, assertiveness training, and relationship-building skills or 2) a wait-list control.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

Skills training resulted in less unprotected anal sex (mean=2.3 for experimental group; 3.3 for control group) and higher condom use during anal sex in the past 4 months (experimental group used condoms during 66% of all anal episodes; 19% for control group). Behavior change maintained at 8-month follow-up
Kelly JA, St. Lawrence JS et al. (1990). A skills-training group intervention model to assist persons in reducing risk behaviors for HIV infection. Education and Prevention 2: 24-35.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV +, unknown, status, or negative high-risk MSM Purpose of study to evaluate impact of more abbreviated intervention than Kelly et al. (1989) above. 15 participants received 7 small group sessions, 60-90 min each. Covered AIDS risk information, behavioral self-management, assertiveness training, pride and support issues. One 3-month follow-up booster session. At 8-month follow-up, UAI in past 4 months fell from .93 to .21 mean occurrences. Proportion of all intercourse occasions where condoms used increased from 72% to 90%. Risk index (risky practices x no of partners) decreased from 4.7 to 1.4.
Rotheram-Borus MJ, Lee MB, Murphy DA et al. (2001) Efficacy of a prevention intervention for youths living with HIV. American Journal of Public Health 91: 400-5.
Subpopulation Researched Intervention Design Evaluated Outcome
Youth/ HIV+
(Mostly MSM)

"Teens Linked to Care"

310 youths, 72% male (mostly MSM) and 28% female, aged 13-24, 27% African-Am and 37% Latino. Study conducted at 9 adolescent clinical care sites in 4 cities. Assigned by small cohort to a 2-module ("Stay Healthy" and "Act Safe") intervention with 23 sessions or to a control condition. In intervention condition, 73% attended at least 1 session. Assessment of module 1 conducted 6 months after completion. Assessment of module 2 conducted 3 months after completion. Cohorts mixed according to sex. (Detailed manual available on web at http://chipts.ucla.edu.) Had difficulty getting youths to attend sessions.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

Following "Stay Healthy" module, number of positive lifestyle changes and active coping styles increased among intervention females vs. control. Social support coping increased for all intervention clients vs. controls. Following "Act Safe" module, intervention youths reported 82% fewer unprotected sexual acts, 45% fewer sexual partners, 50% fewer HIV negative partners, and 31% less substance use than controls.
Rhodes, F., Wood, MM, Hershberger S (2000) A cognitive-behavioral intervention to reduce HIV risk among active drug users. In staying negative in a positive world: HIV prevention strategies that work (pp. 113-124). Sacramento: California Department of Health Services, Office of AIDS.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + or negative IDUs

"Safety Counts"

This intervention (Safety Counts) is aimed at reducing high-risk drug use and sexual behaviors of injective drug and crack cocaine users not in treatment. This seven-session behaviorally focused intervention includes both structured and unstructured psychoeducational activities. These sessions were both in group and individual settings over four to six months.

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

Participants were more than 2.5 times more likely to self-report an increase in condom use at follow-up (5-9 months following enrollment). They were also more likely to report a reduction in the number of times they inject and more likely to test negative for opiates through urinalysis. Plus, they were also more likely to enter drug treatment.
Margolin A, Avants SK, Warburton LA, Hawkins KA, Shi J. (2003). A randomized clinical trial of a manual-guided risk reduction intervention for HIV-positive injecting drug users. Health Psychology, 22(2) 223-228.
Subpopulation Researched Intervention Design Evaluated Outcome
HIV + IDUs

"Holistic Harm Reduction Program (HHRP)"

This intervention uses a 12-session, manual-guided, group level program to reduce harm, promote health, and improve quality of life. The program is based on the Information, Motivation, Behavior (IMB) model of behavior change. In this program, HIV positive IDUs are viewed as autonomous individuals responsible for making informed choices concerning behaviors that pose risk to themselves and others.  Activities in this intervention are designed to address clients as complex human beings is search of physical emotional, social, and spiritual well-being.

HHRP training manuals and other intervention materials

This intervention was outlined in CDC’s Procedural Guidance for selected strategies and interventions for CBOs under Program Announcement 04064.

Participants in this intervention exhibited many significant improvements. They included: measures of addiction severity, harm reduction behaviors, harm reduction knowledge, motivation, behavioral skills, and quality of life. After three months, the participants displayed a greater improvement in behavioral skills and showed a continued decrease in addiction severity and risk behavior. Members in a control group did not maintain gains.
Partner Notification - HIV Positive Person                                                               Back to Top
Partner Counseling and Referral Services to Identified Persons with Undiagnosed HIV---North Carolina.  MMWR December 5, 2003/52 (48); 1181-1184
Subpopulation Researched Intervention Design Evaluated Outcome
In 1989, North Carolina Department of Health and Human Services began offering PCRS to clients who tested positive in confidential and anonymous testing venues.  HIV infection became reportable in 1990 and anonymous testing was discontinued in 1997.  A trained disease intervention specialist (DIS) completed six important steps.  All notified partners received risk reduction counseling and appropriate referrals. Data collected from 2001 revealed a total of 1,603 persons were newly reported to have HIV infections.  DIS were assigned to conduct PCRS with 1,580 (99%) index clients, 1,378 (87%) were located and PCRS identified 1,532 sex or needle sharing partners.  1,359 partners were located and notified of their possible exposure to HIV.  After PCRS, from those who not previously testing positive for HIV, 108 newly tested partners were diagnosed HIV positive.

CDC Technical Guidance for Partner Notification and Referral Services

Procedural Guidance for Implementation of Partner Notification and Referral Services (Adobe Acrobat, 33 pages)  An alternative format of this publication is also available upon request.

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Last Update: 06/24/2008