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Adverse Events to the Smallpox Vaccination


Reporting Adverse Events from Smallpox (Vaccinia) Vaccine

Adverse events specifically related to smallpox (vaccinia) vaccination include:

  • inadvertent inoculation

  • generalized vaccinia

  • eczema vaccinatum

  • progressive vaccinia

  • post-vaccinial encephalitis

  • fetal vaccinia, and

  • bacterial infections of the vaccination site.

Acute allergic reactions (anaphylaxis) and erythema multiforme may also occur.

Unlike other vaccines, an adverse event may occur not only in the person vaccinated (vaccinee), but among their close contacts as well (secondary vaccinia). 

Serious adverse events (life-threatening or requiring CDC consultation or investigational drug treatment) should be reported immediately by telephone to the DOH Communicable Disease Epidemiology 24-hour telephone hotline at 206-418-5500 or toll-free at 1-877-593-4344, unless instructed otherwise by your local health department.

A clinician will be available for consultation, and instructions on completing and submitting a Vaccine Adverse Events Reporting System (VAERS) form will be given at that time. VAERS forms should be faxed within 24 hours to the DOH Communicable Disease Epidemiology confidential fax line at 206-361-2930.

Other adverse events should be reported by telephone or fax within 48 hours to your local health department or DOH Communicable Disease Epidemiology at the telephone or fax numbers above.

Last guideline update
Feb. 2003

Adverse Events to the Smallpox Vaccination

Smallpox Vaccine Reaction Reporting

VAERS Reporting Info
VAERS Reporting Q&A

Additional Smallpox Vaccine Information

Smallpox Vaccination: Evaluation and Follow-up
(PDF format)
(PowerPoint format)
CDC Information on Adverse Reactions
For additional information
contact your local health jurisdiction

General Immunization Reaction Reporting

Surveillance and Reporting Guidelines
(Web Format)
Surveillance and Reporting Guidelines
(PDF format)

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Communicable Disease Epidemiology
Office of Epidemiology
Washington State Department of Health
MS: K17-9, 1610 NE 150th St.
Shoreline, WA 98155-9701

Consultation and technical assistance are available to local health jurisdictions in Washington State:
Phone (206) 418-5500

FAX (206) 418-5515

24-hour contact (inside Washington State only)  1-877-539-4344

Washington residents can contact their local health jurisdictions for assistance


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